Healthcare Professionals
Our Products
Request Product Demo
Surgical specialties
Cardiac
General
Gynecology
Urology
Our Company
What We Do
Who We Are
Careers
CONTACT
C
OR-
K
NOT
®
The Gold Standard for Suture Security
Reduce the risk of PVL
and
mitral prosthetic dehiscence
with the
proven strength and consistency
of
C
OR-
K
NOT
® technology.
⤓ Download Informational Brochure
Time Savings
Improved Security
Reduced Endocarditis
C
OR-
K
NOT
®
Research Database
Reduced Paravalvular Leak
C
OR-
K
NOT
® can reduce PVL rate by >5x
“Clinical Outcomes of Patients More Than One Year after Minimally Invasive Mitral Valve Repair and Replacement Surgery with Sutures Secured using Automated Titanium Fasteners.”
R. Rodriguez, F. Sutter, L. Samules, D. Ice, S. Morrissey, K. Holzerman, S. Goldman. ISMICS Meeting, June 2013.
“Titanium Fasteners During Aortic Valve Replacements: Assessment of Safety and Efficacy.”
J. Wong, V. Kadiyala, A. Forrest, H. DeSelms, D. Joshi, A. Melvin, J. Siordia, G. Hicks, S. Prasad, P. Knight. ISMICS Meeting, June 2017.
“Comparison of Hand-Tied Suture Versus Titanium Fastener in Structural Cardiac Surgery: A Retrospective Single-Center Analysis.”
L. Allaham, S. Al Najar, Y. Elayan, M. Aweel, R. Rabadi, K. Purrman, A. Goodman, M. Bhatti, M. Lutz, A. Allaham. Journal of the Heart Valve Society, January/March 2025.
“Automated Fastener (Core-Knot) versus Manually Tied Knots in Patients Undergoing Aortic Valve Replacement: Impact on Cross-Clamp Time and Short-Term Echocardiographic Results.”
D. Loberman, R. Mohr, P. Pirundini, F. Yazdchi, D. Rinewalt, T. Ziv-Baran. Medicine, August 2018.
“Use of COR-KNOT Device Decreases the Incidence of Paravalvular Leaks During Aortic Valve Replacement.”
K. Plestis, B. Sparks, C. Orlov, O. Orlov, M. Thomas, R. Rodriguez, S. Goldman. ISMICS Meeting, June 2017.
“Transcatheter versus Minimally Invasive Surgical Aortic Valve Replacement: A Propensity Score-Matched Analysis in Low-Risk Patients."
M. Lutz, S. Cavanaugh, S. Martin, A. Gleboff, K. Dilip, A. Nazem, A. Cherney, Z. Zhou, C. Lutz. JTCVS Open, May 2025.
View All Security Research
Reduced Mitral Prosthetic Dehiscence
C
OR-
K
NOT
® can reduce the risk of prosthetic dehiscence by 2x for prosthetic valves and 3.8x for annuloplasty prostheses
Read Prosthetic Dehiscence Study
Strong and Consistent Fastening
C
OR-
K
NOT
® provides suture securing that is twice as strong and significantly more consistent
Hover For
Pressure
Typography
Read Prosthetic Aortic Valve Fixation Study
Read Ex Vivo Model Study
C
OR-
K
NOT
® Clinical Benefits & Research
Explore the clinical benefits of C
OR-
K
NOT
® and the peer-reviewed research supporting its performance
Time Savings
Improved Security
Reduced Endocarditis
C
OR-
K
NOT
®
Research Database
EXPERIENCE THE COR-KNOT®
Request a demo and take the first step toward introducing LSI technology at your hospital.
REQUEST DEMO
